3-Fluoro-4-(3-cyano-1-pyrrolyl)nitrobenzene → 5-Amino-2-(3-cyano-1-pyrrolyl)fluorobenzene

HRID 1167465Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1167465
[F:1][C:2]1[CH:3]=[C:4]([N+:15]([O-])=O)[CH:5]=[CH:6][C:7]=1[N:8]1[CH:12]=[CH:11][C:10]([C:13]#[N:14])=[CH:9]1>CO.[Pd]>[NH2:15][C:4]1[CH:5]=[CH:6][C:7]([N:8]2[CH:12]=[CH:11][C:10]([C:13]#[N:14])=[CH:9]2)=[C:2]([F:1])[CH:3]=1

Komponenten

4

Edukt 1

HCID 229960033-Fluoro-4-(3-cyano-1-pyrrolyl)nitrobenzene

Produkt 1

HCID 229961405-Amino-2-(3-cyano-1-pyrrolyl)fluorobenzene

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

3-Fluoro-4-(3-cyano-1-pyrrolyl)nitrobenzene (5.3 g, 22.9 mmnol) was dissolved in hot MeOH (250 ml) and palladium catalyst (10% on charcoal, 700 mg) added under a nitrogen atmosphere. The mixture was cooled and hydrogenated at atmospheric pressure for 3.5 hours. After filtration through celite, the solution was evaporated to dryness to give title product in sufficent purity for the next stage (4.6 g).

Aufarbeitung

  1. temperatureThe mixture was cooled
  2. filtrationAfter filtration through celite
  3. customthe solution was evaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-312b9797beda4aba96ca2a5a0f066241
Quelldatensatz
uspto-grants-2003_09
Patentnummer
US06617339B1

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