Chloroform → 7,9-Dibromo-beta-carboline hydrochloride

HRID 1168719Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1168719
[Br:1][C:2]1[CH:14]=[C:13]2[C:5]([C:6]3[CH:7]=[CH:8][N:9]=[CH:10][C:11]=3[NH:12]2)=[CH:4][CH:3]=1.[Br:15]Br.C(Cl)(Cl)[Cl:18]>C1COCC1>[ClH:18].[Br:1][C:2]1[CH:14]=[C:13]2[C:5]([C:6]3[CH:7]=[CH:8][N:9]=[CH:10][C:11]=3[N:12]2[Br:15])=[CH:4][CH:3]=1

Komponenten

5

Edukt 3

HCID 6212ChloroformHCID 24408BromineHCID 145928Eudistomin O

Produkt 1

HCID 221852417,9-Dibromo-beta-carboline hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A solution of the product from example 1 (140 mg, 0.58 mmol) in THF (2 ml) was treated with bromine (0.50 ml). After 10 min at RT, the reaction was diluted with chloroform and the product was filtered. The filtered product was taken up in methanol and treated with 1M HCl in ether and concentrated. The residue was triturated with ether to provide 160 mg of 7,9-dibromo-β-carboline hydrochloride.

Aufarbeitung

  1. filtrationthe product was filtered
  2. additiontreated with 1M HCl in ether
  3. concentrationconcentrated
  4. customThe residue was triturated with ether

Quellen und Nachweise

ORD-Eintrag
ord-52b42d2aed7643979ed7dd67d71e2d1c
Quelldatensatz
uspto-grants-2003_09
Patentnummer
US06627637B2

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