3-(Trifluoromethyl)aniline → Diethyl ((alpha,alpha,alpha-trifluoro-m-toluidino)methylene)malonate

HRID 1168772

Reaktionsgleichung

Reaktionsgleichung von HRID 1168772
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:4]=[C:5]([CH:7]=[CH:8][CH:9]=1)[NH2:6].C(O[CH2:15][CH:16]([C:22]([O:24][CH2:25][CH3:26])=[O:23])[C:17]([O:19][CH2:20][CH3:21])=[O:18])C>>[F:1][C:2]([F:10])([F:11])[C:3]1[CH:4]=[C:5]([CH:7]=[CH:8][CH:9]=1)[NH:6][CH:15]=[C:16]([C:17]([O:19][CH2:20][CH3:21])=[O:18])[C:22]([O:24][CH2:25][CH3:26])=[O:23]

Komponenten

3

Edukt 2

HCID 73753-(Trifluoromethyl)anilineHCID 98702Diethyl (ethoxymethyl)malonate

Produkt 1

HCID 96560Diethyl ((alpha,alpha,alpha-trifluoro-m-toluidino)methylene)malonate

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

Under a nitrogen atmosphere, a mixture of 3-(trifluoromethyl)aniline (40 mL, 0.32 mmol) and diethyl ethoxymethylmalonate was heated at 100° C. for 3 hours. The reaction mixture was allowed to cool to room temperature at which time the solution solidified to provide 102 g of diethyl 2-{[3-(trifluoromethyl)anilino]methylene}malonate as a cream colored solid.

Aufarbeitung

  1. temperatureto cool to room temperature at which time the solution

Quellen und Nachweise

ORD-Eintrag
ord-7b6920eac5bd4b2fae1f6cdf91498fb5
Quelldatensatz
uspto-grants-2003_09
Patentnummer
US06627638B2

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