Benzyl 2-[4-(tert-butoxycarbonylamino)piperidin-1-yl]ethylcarbamate → 1,1-Dimethylethyl N-[1-(2-aminoethyl)-4-piperidinyl]carbamate

HRID 1169405

Reaktionsgleichung

Reaktionsgleichung von HRID 1169405
[C:1]([O:5][C:6]([NH:8][CH:9]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][NH:17]C(=O)OCC2C=CC=CC=2)[CH2:11][CH2:10]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>[Pd].C(O)C>[NH2:17][CH2:16][CH2:15][N:12]1[CH2:13][CH2:14][CH:9]([NH:8][C:6](=[O:7])[O:5][C:1]([CH3:3])([CH3:2])[CH3:4])[CH2:10][CH2:11]1

Komponenten

4

Edukt 1

HCID 22989976Benzyl 2-[4-(tert-butoxycarbonylamino)piperidin-1-yl]ethylcarbamate

Produkt 1

HCID 235626471,1-Dimethylethyl N-[1-(2-aminoethyl)-4-piperidinyl]carbamateAusbeute 124,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of benzyl 2-[4-(tert-butoxycarbonylamino)piperidin-1-yl]ethylcarbamate (3.0 g), Pd-C (0.3 g), and ethanol (100 ml) was stirred vigorously for 3 days under a hydrogen atmosphere. Pd-C was removed by filtration, and the filtrate was concentrated under reduced pressure to obtain tert-butyl 1-(2-aminoethyl)-4-piperidinylcarbamate (2.4 g) as a colorless oily substance.

Aufarbeitung

  1. customPd-C was removed by filtration
  2. concentrationthe filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-29e43d51fbee459a8113259ad8adbd7c
Quelldatensatz
uspto-grants-2003_09
Patentnummer
US06627651B1

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