Lithium Hydroxide → 4-(4-Methoxybenzyloxy) benzoic acid

HRID 1170690Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1170690
[CH3:1][O:2][C:3]1[CH:20]=[CH:19][C:6]([CH2:7][O:8][C:9]2[CH:18]=[CH:17][C:12]([C:13]([O:15]C)=[O:14])=[CH:11][CH:10]=2)=[CH:5][CH:4]=1.[OH-].[Li+]>O1CCOCC1>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:7][O:8][C:9]2[CH:18]=[CH:17][C:12]([C:13]([OH:15])=[O:14])=[CH:11][CH:10]=2)=[CH:19][CH:20]=1

Komponenten

4

Edukt 2

HCID 3939Lithium HydroxideHCID 12648420Methyl 4-[(4-methoxyphenyl)methoxy]benzoate

Produkt 1

HCID 113344014-(4-Methoxybenzyloxy) benzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

To a solution of methyl 4-(4-methoxybenzyloxy)benzoate (12.2 g, 44.8 mmole) in 50 ml 1,4-dioxane was added a solution of lithium hydroxide (2.15 g, 89.6 mmole) and the mixture was stirred overnight at 60° C. The mixture was evaporated under reduced pressure and 5% acetic acid was added. The product was filtered, washed with water and dried. Yield: 10.1 g=87%

Aufarbeitung

  1. customThe mixture was evaporated under reduced pressure and 5% acetic acid
  2. additionwas added
  3. filtrationThe product was filtered
  4. washwashed with water
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-b259f358925f4fd38d6eaaf1dc6e4c97
Quelldatensatz
uspto-grants-2010_11
Patentnummer
US07825238B2

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