Sodium Iodide → HCID 18400042, Verbindung

HRID 1170692Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1170692
[CH3:1][O:2][C:3]1[CH:21]=[CH:20][C:6]([CH2:7][O:8][C:9]2[CH:19]=[CH:18][C:12]([C:13]([O:15][CH2:16]Cl)=[O:14])=[CH:11][CH:10]=2)=[CH:5][CH:4]=1.[I-:22].[Na+]>CC(C)=O>[CH3:1][O:2][C:3]1[CH:21]=[CH:20][C:6]([CH2:7][O:8][C:9]2[CH:19]=[CH:18][C:12]([C:13]([O:15][CH2:16][I:22])=[O:14])=[CH:11][CH:10]=2)=[CH:5][CH:4]=1

Komponenten

4

Edukt 2

HCID 5238Sodium IodideHCID 22035697HCID 22035697, Verbindung

Produkt 1

HCID 18400042HCID 18400042, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

To a solution of chloromethyl 4-(4-methoxybenzyloxy)benzoate (0.77 g, 2.5 mmole) in 15 ml dry acetone was added sodium iodide (1.87 g, 12.5 mmole) and the mixture was stirred overnight at room temperature. The mixture was evaporated under reduced pressure and extracted with ethyl acetate/water. The organic phase was washed with a 5% sodium thiosulfate solution, dried with sodium sulfate and evaporated under reduced pressure. Yield 0.86 g=86%

Aufarbeitung

  1. customThe mixture was evaporated under reduced pressure
  2. extractionextracted with ethyl acetate/water
  3. washThe organic phase was washed with a 5% sodium thiosulfate solution
  4. dry with materialdried with sodium sulfate
  5. customevaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-0e83f2d75aaa4a5cbd831091812e3581
Quelldatensatz
uspto-grants-2010_11
Patentnummer
US07825238B2

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