Hydrochloric Acid → (S)-mandelic acid

Temperatur

1 °C

The L-mandelate (S,R,R salt 2, 274 g, 1.03 mol) was dissolved in water (400 ml) and brought to pH 1.5 by adding concentrated hydrochloric acid. The mixture was cooled to 1° C. and seeded by adding a few crystals of S-mandelic acid. The mixture was stirred at 0° C. for a further 2 hours and the precipitated crystal slurry was filtered with suction. The filter residue was washed with ice-water (100 ml) and dried at 50° C. under reduced pressure. 86 g (57%) of L-mandelic acid were obtained, which were optically pure according to analysis.

1. filtrationthe precipitated crystal slurry was filtered with suction
2. washThe filter residue was washed with ice-water (100 ml)
3. customdried at 50° C. under reduced pressure

ORD-Eintrag

ord-a33c80d9c77049f1ab953f801eddba31

Quelldatensatz

uspto-grants-2010_11

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07829702B2