[2-(2-Ethyl-5-methyl-2H-pyrazol-3-yl)-ethyl]-carbamic acid benzyl ester → 2-(2-Ethyl-5-methyl-2H-pyrazol-3-yl)-ethylamine

HRID 1172585Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1172585
C(OC(=O)[NH:10][CH2:11][CH2:12][C:13]1[N:14]([CH2:19][CH3:20])[N:15]=[C:16]([CH3:18])[CH:17]=1)C1C=CC=CC=1>CO.[Pd]>[CH2:19]([N:14]1[C:13]([CH2:12][CH2:11][NH2:10])=[CH:17][C:16]([CH3:18])=[N:15]1)[CH3:20]

Komponenten

4

Edukt 1

HCID 57659607[2-(2-Ethyl-5-methyl-2H-pyrazol-3-yl)-ethyl]-carbamic acid benzyl ester

Produkt 1

HCID 451214772-(2-Ethyl-5-methyl-2H-pyrazol-3-yl)-ethylamineAusbeute 93,7 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel2×

Versuchsvorschrift

[2-(2-Ethyl-5-methyl-2H-pyrazol-3-yl)-ethyl]-carbamic acid benzyl ester (818 mg, 2.85 mmol) was dissolved in methanol (8 ml) and added to a suspension of Pd—C (10%, 163 mg) in methanol (8 ml), put under an atmosphere of hydrogen (1 bar) and stirring at rt was continued for 45 minutes. The reaction mixture was filtered over a pad of celite and the filtrate was concentrated under reduced pressure to give 408 mg (93.7%) of 2-(2-Ethyl-5-methyl-2H-pyrazol-3-yl)-ethylamine. LC-MS: tR=0.20 min, broad peak; [M+H]+=no ionization.

Aufarbeitung

  1. filtrationThe reaction mixture was filtered over a pad of celite
  2. concentrationthe filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-b479686c909c42a99535e1ec7e18087e
Quelldatensatz
uspto-grants-2010_11
Patentnummer
US07834028B2

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