Potassium Hydroxide → 955403-63-1

HRID 1172597Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1172597
[OH-].[K+].C([O:5][C:6](=[O:22])[CH:7]([CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([CH3:20])[C:15]=1[F:21])C(OCC)=O)C>O>[F:21][C:15]1[C:16]([CH3:20])=[CH:17][CH:18]=[CH:19][C:14]=1[CH2:13][CH2:7][C:6]([OH:22])=[O:5]

Komponenten

4

Edukt 2

HCID 14797Potassium HydroxideHCID 57659600HCID 57659600, Verbindung

Produkt 1

HCID 57659614955403-63-1Ausbeute 69,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

Potassium hydroxide (387 mg, 6.9 mmol) was dissolved in water (8 ml) followed by the addition of 2-(2-fluoro-3-methyl-benzyl)-malonic acid diethyl ester (973 mg, 3.44 mmol). The mixture was refluxed for 5 h followed by removal of the ethanol under reduced pressure. Concentrated sulfuric acid (0.59 ml) was added to the remaining aqueous solution and refluxing was continued for 18 h. The reaction mixture was cooled to 0° C. and the precipitated product was filtered off, washed with water and dried at HV to give 433 mg (69%) of 3-(2-fluoro-3-methyl-phenyl)-propionic acid. LC-MS: tR=0.84 min; [M+H]+=183.20.

Aufarbeitung

  1. temperatureThe mixture was refluxed for 5 h
  2. customfollowed by removal of the ethanol under reduced pressure
  3. additionConcentrated sulfuric acid (0.59 ml) was added to the remaining aqueous solution
  4. temperaturerefluxing
  5. filtrationthe precipitated product was filtered off
  6. washwashed with water
  7. customdried at HV

Quellen und Nachweise

ORD-Eintrag
ord-73d7330637ea45c59c7fa88a12a9160a
Quelldatensatz
uspto-grants-2010_11
Patentnummer
US07834028B2

Notizen zur Reaktion

Wird geladen…