1,2-Epoxy-3-fluoropropane → 1-Fluoro-3-[4-(4-nitrophenyl)piperazin-1-yl]propan-2-ol

HRID 1172624

Reaktionsgleichung

Reaktionsgleichung von HRID 1172624
[CH2:1]([CH:3]1[O:5][CH2:4]1)[F:2].[N+:6]([C:9]1[CH:14]=[CH:13][C:12]([N:15]2[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)=[CH:11][CH:10]=1)([O-:8])=[O:7]>C(O)C>[F:2][CH2:1][CH:3]([OH:5])[CH2:4][N:18]1[CH2:19][CH2:20][N:15]([C:12]2[CH:11]=[CH:10][C:9]([N+:6]([O-:8])=[O:7])=[CH:14][CH:13]=2)[CH2:16][CH2:17]1

Komponenten

4

Edukt 2

HCID 104181,2-Epoxy-3-fluoropropaneHCID 804471-(4-Nitrophenyl)piperazine

Produkt 1

HCID 671710891-Fluoro-3-[4-(4-nitrophenyl)piperazin-1-yl]propan-2-olAusbeute 43,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

Ethanol (15 mL) solution of 272 mg of epifluorohydrin and 500 mg of 1-(4-nitrophenyl)piperazine was heated under reflux for 15 hours, and then the reaction liquid was concentrated under reduced pressure. The residue was solidified from ethyl acetate to obtain 300 mg of the entitled compound as a yellow solid.

Aufarbeitung

  1. temperatureunder reflux for 15 hours
  2. customthe reaction liquid
  3. concentrationwas concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-a96acaf4421942fbb6db7b3ca2629fde
Quelldatensatz
uspto-grants-2010_11
Patentnummer
US07834019B2

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