4-Fluoro-2-vinyl-benzonitrile → 2-Ethyl-4-fluorobenzonitrile

HRID 1172681Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1172681
[F:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([CH:10]=[CH2:11])[CH:3]=1>CO.[Pd]>[CH2:10]([C:4]1[CH:3]=[C:2]([F:1])[CH:9]=[CH:8][C:5]=1[C:6]#[N:7])[CH3:11]

Komponenten

4

Edukt 1

HCID 595563374-Fluoro-2-vinyl-benzonitrile

Produkt 1

HCID 234392762-Ethyl-4-fluorobenzonitrileAusbeute 77,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

800 mg 4-Fluoro-2-vinyl-benzonitrile were dissolved in 5 ml methanol. 80 mg palladium (10% on charcoal) were added and the reaction was stirred under a hydrogen atmosphere for one hour. The catalyst was filtered off trough a pad of celite. The filtrate was evaporated to obtain 625 mg 2-Ethyl-4-fluoro-benzonitrile.

Aufarbeitung

  1. filtrationThe catalyst was filtered off trough a pad of celite
  2. customThe filtrate was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-2b38a61d2c924003b8d6f911058d88ae
Quelldatensatz
uspto-grants-2010_11
Patentnummer
US07834030B2

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