Benzoyl Peroxide → NCS Chloride

HRID 1172906

Reaktionsgleichung

Reaktionsgleichung von HRID 1172906
FC1C=CC=C(C)N=1.[CH2:9]1[C:14](=[O:15])[N:13]([Cl:16])[C:11](=[O:12])[CH2:10]1.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C1C=CC=CC=1>[CH2:9]1[C:14](=[O:15])[N:13]([Cl:16])[C:11](=[O:12])[CH2:10]1.[Cl-:16]

Komponenten

5

Edukt 3

HCID 7187Benzoyl PeroxideHCID 31398ChlorosuccinimideHCID 960902-Fluoro-6-methylpyridine

Produkt 1

HCID 86612418NCS Chloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel

Versuchsvorschrift

2-Fluoro-6-methylpyridine (1.11 g, 10 mmol), NCS (2.0 g, 15 mmol), and catalytic benzoyl peroxide were dissolved in benzene and heated to reflux overnight. The reaction was concentrated and diluted with water and EtOAc. The organic layer was washed with saturated aq. NaHCO3, dried, filtered, and concentrated. The residue was purified on silica gel to give the desired product.

Aufarbeitung

  1. temperatureheated
  2. temperatureto reflux overnight
  3. concentrationThe reaction was concentrated
  4. additiondiluted with water and EtOAc
  5. washThe organic layer was washed with saturated aq. NaHCO3
  6. customdried
  7. filtrationfiltered
  8. concentrationconcentrated
  9. customThe residue was purified on silica gel

Quellen und Nachweise

ORD-Eintrag
ord-a18073d4cb274e4581bd4cd9f8eff6e5
Quelldatensatz
uspto-grants-2010_11
Patentnummer
US07834037B2

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