Pyridine → HCID 22674187, Verbindung

HRID 1173137Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1173137
N1C=CC=CC=1.[Cl:7][C:8]1[CH:13]=[CH:12][C:11]([S:14](Cl)(=[O:16])=[O:15])=[CH:10][CH:9]=1.[NH2:18][C:19]1[CH:28]=[CH:27][C:26]2[C:21](=[CH:22][CH:23]=[CH:24][C:25]=2[Cl:29])[N:20]=1>O>[Cl:7][C:8]1[CH:13]=[CH:12][C:11]([S:14]([NH:18][C:19]2[CH:28]=[CH:27][C:26]3[C:21](=[CH:22][CH:23]=[CH:24][C:25]=3[Cl:29])[N:20]=2)(=[O:16])=[O:15])=[CH:10][CH:9]=1

Komponenten

5

Edukt 3

HCID 1049PyridineHCID 73984-Chlorobenzenesulfonyl chlorideHCID 140674265-Chloroquinolin-2-amine

Produkt 1

HCID 22674187HCID 22674187, VerbindungAusbeute 8,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

Pyridine (1 ml) and 4-chlorobenzenesulfonyl chloride (255 mg) were added to 2-amino-5-chloroquinoline (119 mg, Production Example 2b) at room temperature, followed by stirring at room temperature for 3 days. Then, water was added thereto, followed by extracting with ethyl acetate. The ethyl acetate layer was dried over sodium sulfate and concentrated. Then, the resulting solid was washed with methanol, to give the title compound (20 mg).

Aufarbeitung

  1. extractionby extracting with ethyl acetate
  2. dry with materialThe ethyl acetate layer was dried over sodium sulfate
  3. concentrationconcentrated
  4. washThen, the resulting solid was washed with methanol

Quellen und Nachweise

ORD-Eintrag
ord-f83542927c7d46d6ad71d7c6634dc643
Quelldatensatz
uspto-grants-2010_11
Patentnummer
US07834049B2

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