N-{6-[(Phenylmethyl)oxy]-3-pyridinyl}acetamide → HCID 178474274, Verbindung
Reaktionsgleichung
C1(C[O:8][C:9]2[N:14]=[CH:13][C:12]([NH:15][C:16](=[O:18])[CH3:17])=[CH:11][CH:10]=2)C=CC=CC=1>CCO.[Pd]>[OH:8][C:9]1[N:14]=[CH:13][C:12]([NH:15][C:16](=[O:18])[CH3:17])=[CH:11][CH:10]=1Komponenten
4
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
To a solution of N-{6-[(phenylmethyl)oxy]-3-pyridinyl}acetamide (0.210 g, 0.87 mmol) in EtOH (10 mL) at rt was added Pd—C (0.046 g of 10 wt % on activated carbon (dry basis), ca. 50 wt % H2O; ca. 0.022 mmol Pd). The mixture was placed under an atmosphere of H2 and stirred for 4.5 h. The mixture was filtered through Celite (EtOAc wash) and concentrated in vacuo, affording 0.132 g of the title compound as a colorless solid: MS (ESI) m/z 152 (M+).
Aufarbeitung
- filtrationThe mixture was filtered through Celite (EtOAc wash)
- concentrationconcentrated in vacuo
Quellen und Nachweise
- ORD-Eintrag
- ord-6253c988063c46f6b92abd8d073f19a3
- Quelldatensatz
- uspto-grants-2010_11
- Patentnummer
- US07834063B2
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