Pyridine → N-(4-bromo-3-chloro-2-fluorophenyl)acetamide

HRID 1173643Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1173643
[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[C:4]([F:9])[C:3]=1[Cl:10].[C:11](OC(=O)C)(=[O:13])[CH3:12].N1C=CC=CC=1>C(OCC)(=O)C>[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:11](=[O:13])[CH3:12])=[C:4]([F:9])[C:3]=1[Cl:10]

Komponenten

5

Edukt 3

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 27827054-Bromo-3-chloro-2-fluoroaniline

Produkt 1

HCID 23273791N-(4-bromo-3-chloro-2-fluorophenyl)acetamideAusbeute 96 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel2×

Versuchsvorschrift

To a solution of 4-bromo-3-chloro-2-fluoroaniline (15.0 g) in ethyl acetate (200 mL) was added dropwise acetic anhydride (7.57 mL) at 0° C. Then, pyridine (10.8 mL) was added dropwise, and the mixture was stirred at room temperature overnight. The mixture was diluted with ethyl acetate, washed with water and saturated brine, and dried over magnesium sulfate. The solvent was evaporated under reduced pressure. The obtained solid was washed with hexane to give the title compound as a colorless solid (yield: 17.1 g, 96%).

Aufarbeitung

  1. washwashed with water and saturated brine
  2. dry with materialdried over magnesium sulfate
  3. customThe solvent was evaporated under reduced pressure
  4. washThe obtained solid was washed with hexane

Quellen und Nachweise

ORD-Eintrag
ord-c7bfd234d29e4d88a6178edb1ae17453
Quelldatensatz
uspto-grants-2010_11
Patentnummer
US07834051B2

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