Methanol → HCID 22298443, Verbindung

Temperatur

70 °C

Ethyl 2-chloro-3-oxohexanoate (2.5 g, 13 mmol), methanol (7.5 ml) and water (0.75 ml) were mixed, and nitrogen substitution was carried out after reducing the pressure. The above catalyst solution was added thereto, and hydrogen substitution (3 atmospheres) was carried out under reduced pressure. The mixture was stirred at 70° C. for 14 hours. After the mixture was cooled to room temperature, the solvent was evaporated away under reduced pressure. The concentrated matter was purified by silica gel column chromatography to obtain the title compound as a colorless oil (1.83 g, yield: 72%) ((2S,3R):(2S,3S):(2R,3S):(2R,3R)=6.2:58.5:33.2:2.2).

1. additionThe above catalyst solution was added
2. temperatureAfter the mixture was cooled to room temperature
3. customthe solvent was evaporated away under reduced pressure
4. customThe concentrated matter was purified by silica gel column chromatography

ORD-Eintrag

ord-8f2a9aadef7a4c1b971c7dc56892c4ea

Quelldatensatz

uspto-grants-2010_11

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07834190B2