Formic Acid → HCID 59203391, Verbindung

HRID 1173777Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1173777
[Cl:1][CH:2]([C:8](=[O:12])[CH2:9][CH2:10][CH3:11])[C:3]([O:5][CH2:6][CH3:7])=[O:4].C(N(CC)CC)C.C(O)=O>CN(C=O)C>[Cl:1][C@@H:2]([C@H:8]([OH:12])[CH2:9][CH2:10][CH3:11])[C:3]([O:5][CH2:6][CH3:7])=[O:4]

Komponenten

5

Edukt 3

HCID 284Formic AcidHCID 8471TriethylamineHCID 11424094Ethyl 2-chloro-3-oxohexanoate

Produkt 1

HCID 59203391HCID 59203391, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

Ethyl 2-chloro-3-oxohexanoate (194 mg), DMF (2.4 ml), RuCl[(S,S)—NpDPEN](p-cymene) complex (1 mol %) and triethylamine (5 equivalents) were mixed, and formic acid (5 equivalents) was gradually added thereto. The reaction was carried out at 40° C. for 3 hours. The reaction mixture was analyzed. As a result, the conversion ratio was 95%, and the isomer ratio of (2S,3R):(2S,3S):(2R,3R):(2R,3S) is 88.3:4.6:2.1:5.1.

Quellen und Nachweise

ORD-Eintrag
ord-e4a1701459304a6e98f373961ca868a8
Quelldatensatz
uspto-grants-2010_11
Patentnummer
US07834190B2

Notizen zur Reaktion

Wird geladen…