1-(Hydroxymethyl)isoquinoline → Isoquinoline-1-carbaldehyde

HRID 1173911

Reaktionsgleichung

Reaktionsgleichung von HRID 1173911
[C:1]1([CH2:11][OH:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][N:2]=1>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[C:1]1([CH:11]=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][N:2]=1

Komponenten

4

Edukt 1

HCID 27762471-(Hydroxymethyl)isoquinoline

Produkt 1

HCID 265306Isoquinoline-1-carbaldehydeAusbeute 85,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418406HCID 178418406, VerbindungKatalysatorHCID 6212ChloroformLösungsmittel

Versuchsvorschrift

Isoquinolin-1-yl-methanol (123.7 mg) was dissolved in chloroform (6.2 ml) and then added with manganese dioxide (chemically processed product) (1.24 g), followed by stirring at room temperature for 30 minutes. The reaction solution was filtrated through Celite and the solvent was then distilled off. The residue was dried under vacuum, thereby obtaining the subject compound (103.9 mg) as a brown solid.

Aufarbeitung

  1. filtrationThe reaction solution was filtrated through Celite
  2. distillationthe solvent was then distilled off
  3. customThe residue was dried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-b1e070c7986146688b54b66074608f16
Quelldatensatz
uspto-grants-2010_11
Patentnummer
US07833991B2

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