Hydrochloric Acid → (2S)-2-({[benzyl(methyl)amino]carbonyl}amino)-3,3-dimethylbutanoic Acid

HRID 1174223Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1174223
[CH2:1]([N:8]([CH3:21])[C:9]([NH:11][C@@H:12]([C:17]([CH3:20])([CH3:19])[CH3:18])[C:13]([O:15]C)=[O:14])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Li+].Cl>O1CCOCC1>[CH2:1]([N:8]([CH3:21])[C:9]([NH:11][C@@H:12]([C:17]([CH3:19])([CH3:18])[CH3:20])[C:13]([OH:15])=[O:14])=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 67408150methyl(2S)-2-({[benzyl(methyl)amino]carbonyl}amino)-3,3-dimethylbutanoate

Produkt 1

HCID 61186392(2S)-2-({[benzyl(methyl)amino]carbonyl}amino)-3,3-dimethylbutanoic Acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Reaktionsbedingungen

Temperatur
25 °C

Versuchsvorschrift

A solution containing the product from Example 63B (0.046 g, 0.057 mmol) in dioxane (1.6 mL) was treated with an aqueous solution of lithium hydroxide (0.63 mL, 0.5 N), and the mixture was stirred at 25° C. for 16 hours. An aqueous HCl solution (0.60 mL, 1N) was added, the reaction mixture was partitioned between ethyl acetate and water, and the organic phase was washed with brine and dried over MgSO4, filtered and concentrated to give the crude product, which was used without further purification.

Aufarbeitung

  1. customthe reaction mixture was partitioned between ethyl acetate and water
  2. washthe organic phase was washed with brine
  3. dry with materialdried over MgSO4
  4. filtrationfiltered
  5. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-b282b8235d7e4ba997e1c9477abb7793
Quelldatensatz
uspto-grants-2010_11
Patentnummer
US07834043B2

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