Methylamine → N-Methyl-6-nitrobenzo[D]thiazol-2-amine
Reaktionsgleichung
Cl[C:2]1[S:3][C:4]2[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[CH:8]=[CH:7][C:5]=2[N:6]=1.[CH3:14][NH2:15]>C1COCC1.O>[CH3:14][NH:15][C:2]1[S:3][C:4]2[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[CH:8]=[CH:7][C:5]=2[N:6]=1Komponenten
5
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
Place 2-chloro-6-nitro-benzothiazole (5.82 g, 27.1 mmol) in THF (130 mL). Add 40% methylamine in water (7 mL) and stir until the product precipitates out. Concentrate in vacuo and then triturate with methanol. Filter off the product and wash with methanol, Dry thoroughly to yield 4.99 g (88%) of the title compound: mass spectrum (ion-spray): (m/z)=210.0 (M+1).
Aufarbeitung
- customprecipitates out
- concentrationConcentrate in vacuo
- customtriturate with methanol
- filtrationFilter off the product
- washwash with methanol
- customDry thoroughly
Quellen und Nachweise
- ORD-Eintrag
- ord-d63f6ac0ae0d46888a58e608370ee763
- Quelldatensatz
- uspto-grants-2010_11
- Patentnummer
- US07838543B2
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