Methylamine → N-Methyl-6-nitrobenzo[D]thiazol-2-amine

HRID 1174960

Reaktionsgleichung

Reaktionsgleichung von HRID 1174960
Cl[C:2]1[S:3][C:4]2[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[CH:8]=[CH:7][C:5]=2[N:6]=1.[CH3:14][NH2:15]>C1COCC1.O>[CH3:14][NH:15][C:2]1[S:3][C:4]2[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[CH:8]=[CH:7][C:5]=2[N:6]=1

Komponenten

5

Edukt 2

HCID 6329MethylamineHCID 754762-Chloro-6-nitrobenzothiazole

Produkt 1

HCID 638568N-Methyl-6-nitrobenzo[D]thiazol-2-amineAusbeute 88 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Place 2-chloro-6-nitro-benzothiazole (5.82 g, 27.1 mmol) in THF (130 mL). Add 40% methylamine in water (7 mL) and stir until the product precipitates out. Concentrate in vacuo and then triturate with methanol. Filter off the product and wash with methanol, Dry thoroughly to yield 4.99 g (88%) of the title compound: mass spectrum (ion-spray): (m/z)=210.0 (M+1).

Aufarbeitung

  1. customprecipitates out
  2. concentrationConcentrate in vacuo
  3. customtriturate with methanol
  4. filtrationFilter off the product
  5. washwash with methanol
  6. customDry thoroughly

Quellen und Nachweise

ORD-Eintrag
ord-d63f6ac0ae0d46888a58e608370ee763
Quelldatensatz
uspto-grants-2010_11
Patentnummer
US07838543B2

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