N-bromobutanimide → Methyl 6-(bromomethyl)pyridine-2-carboxylate

HRID 1176757

Reaktionsgleichung

Reaktionsgleichung von HRID 1176757
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH3:11])[N:6]=1)=[O:4].C1C(=O)N([Br:19])C(=O)C1>C(Cl)(Cl)(Cl)Cl.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH2:11][Br:19])[N:6]=1)=[O:4]

Komponenten

5

Edukt 2

HCID 67184N-bromobutanimideHCID 73022Methyl 6-methylpyridine-2-carboxylate

Produkt 1

HCID 21471714Methyl 6-(bromomethyl)pyridine-2-carboxylateAusbeute 20,2 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 7187Benzoyl PeroxideKatalysatorHCID 5943Carbon TetrachlorideLösungsmittel

Versuchsvorschrift

6-Bromomethyl-pyridine-2-carboxylic acid methyl ester was prepared according to Wells, G. J. et al. (WO 94/11398): A mixture of 6-methyl-pyridine-2-carboxylic acid methyl ester (6.5 g, 43.0 mmol), benzoyl peroxide (25 mg, 0.1 mmol) and NBS (8.5 g, 47.8 mmol) in carbon tetrachloride (250 mL) was heated at reflux overnight. The reaction mixture was cooled to room temperature, filtered, evaporated, and purified by chromatography on flash silica gel, eluting with 15% ethyl acetate/hexane to give 6-bromomethyl-pyridine-2-carboxylic acid methyl ester (2.0 g, 20%) as a white solid. 1HNMR (CDCl3): δ 8.06 (d, J=8.0 Hz, 1H), 7.87 (dd, J=8.0 Hz, 1H), 7.70 (d, J=8.0 Hz, 1H), 4.65 (s, 2H), 4.02 (s, 3H). MS (APCI+): 231 (45), 235 (42).

Aufarbeitung

  1. custom6-Bromomethyl-pyridine-2-carboxylic acid methyl ester was prepared
  2. temperaturewas heated
  3. temperatureat reflux overnight
  4. filtrationfiltered
  5. customevaporated
  6. custompurified by chromatography on flash silica gel
  7. washeluting with 15% ethyl acetate/hexane

Quellen und Nachweise

ORD-Eintrag
ord-d9673c2fb2bc45969f422b986ec8dc57
Quelldatensatz
uspto-grants-2010_11
Patentnummer
US07842825B2

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