3-(1-Benzothiophen-3-yl)prop-2-enoic acid → 3-(1-Benzothiophen-3-yl)propanoic acid

HRID 1177756Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1177756
[S:1]1[CH:5]=[C:4]([CH:6]=[CH:7][C:8]([OH:10])=[O:9])[C:3]2[CH:11]=[CH:12][CH:13]=[CH:14][C:2]1=2>[Pd].CO.C(OCC)(=O)C>[S:1]1[CH:5]=[C:4]([CH2:6][CH2:7][C:8]([OH:10])=[O:9])[C:3]2[CH:11]=[CH:12][CH:13]=[CH:14][C:2]1=2

Komponenten

4

Edukt 1

HCID 534270043-(1-Benzothiophen-3-yl)prop-2-enoic acid

Produkt 1

HCID 123189833-(1-Benzothiophen-3-yl)propanoic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 21584119Ethylacetate methanolLösungsmittel

Versuchsvorschrift

A suspension of 3-benzo[b]thiophen-3-yl-acrylic acid: (5.6 g, 0.027 mol) and 10% Pd/C (600 mg) in 1:1 methanol/ethyl acetate (50 mL) was hydrogenated in a Parr apparatus at 50 psi overnight. The mixture was filtered and concentrated to give the crude product without further purification (ca. 100% conversion). Mass spec.: 205(MH)−.

Aufarbeitung

  1. customwas hydrogenated in a Parr apparatus at 50 psi overnight
  2. filtrationThe mixture was filtered
  3. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-9351739e3f744f70990306e06fc02f0e
Quelldatensatz
uspto-grants-2010_11
Patentnummer
US07842808B2

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