Water → 6-(Benzyloxy)pyridine-3-carboxylic acid

To a stirred solution of 6-benzyloxy-nicotinonitrile (100 mg, 0.47 mmol) in a mixture of EtOH (5 mL) and water (5 mL), was added NaOH (95.1 mg, 2.3 mmol) and the resulting mixture was stirred at 90° C. for 20 hrs. The mixture was evaporated under reduced pressure. The residue was diluted with cold water, adjusted the pH to 3 and extracted with EtOAc. The organic layer was washed with saturated brine solution and dried over Na2SO4. The organic layer was then concentrated under reduced pressure to afford 105 mg (96% yield) of 6-benzyloxy-nicotinic acid.

1. customThe mixture was evaporated under reduced pressure
2. additionThe residue was diluted with cold water
3. extractionextracted with EtOAc
4. washThe organic layer was washed with saturated brine solution
5. dry with materialdried over Na2SO4
6. concentrationThe organic layer was then concentrated under reduced pressure

ORD-Eintrag

ord-ccb10e5e37cd4352855a1a32139f9d51

Quelldatensatz

uspto-grants-2010_11

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07842696B2