Hydrogen Bromide → 1-(Bromomethyl)-2-(trifluoromethyl)benzene

HRID 1178015

Reaktionsgleichung

Reaktionsgleichung von HRID 1178015
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:10]=[CH:9][CH:8]=[CH:7][C:4]=1[CH2:5]O.[BrH:13]>O>[F:1][C:2]([F:12])([F:11])[C:3]1[CH:10]=[CH:9][CH:8]=[CH:7][C:4]=1[CH2:5][Br:13]

Komponenten

4

Edukt 2

HCID 260Hydrogen BromideHCID 676662-(Trifluoromethyl)benzylic alcohol

Produkt 1

HCID 1230571-(Bromomethyl)-2-(trifluoromethyl)benzene

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of 2-trifluoromethyl benzyl alcohol (1 g, 5.67 mmol) in aqueous HBr (6 mL) was stirred at 50° C. for 4 hrs. The reaction mixture was diluted with cold water and the product extracted with ethyl acetate. The organic layer was washed with saturated brine solution, dried over sodium sulphate and concentrated to afford 780 mg of 2-trifluoromethylbenzyl bromide.

Aufarbeitung

  1. extractionthe product extracted with ethyl acetate
  2. washThe organic layer was washed with saturated brine solution
  3. dry with materialdried over sodium sulphate
  4. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-de488eae72364be98e4a6cd3d7e791fe
Quelldatensatz
uspto-grants-2010_11
Patentnummer
US07842696B2

Verknüpfte Notizen

Wird geladen…