Neopentylamine → HCID 178446492, Verbindung

HRID 1179680Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1179680
[OH:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[CH:4][N:3]=1.ON1C2N=CC=CC=2N=N1.Cl.CN(C)CCCN=C=NCC.[CH3:33][C:34]([CH3:38])([CH3:37])[CH2:35][NH2:36].C(N(CC)C(C)C)(C)C>CN(C)C=O.C(OCC)(=O)C>[CH3:33][C:34]([CH3:38])([CH3:37])[CH2:35][NH:36][C:6](=[O:8])[C:5]1[CH:9]=[CH:10][C:2]([OH:1])=[N:3][CH:4]=1

Komponenten

8

Edukt 5

HCID 79882NeopentylamineHCID 81531DiisopropylethylamineHCID 181649HOAtHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 178418479HCID 178418479, Verbindung

Produkt 1

HCID 178446492HCID 178446492, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideLösungsmittel2×HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

A solution of 6-hydroxynicotinic acid (1.39 g, 10.0 mmol), 1-hydroxy-7-azabenztriazole (1.50 g, 11.0 mmol), and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (2.11 g, 11.0 mmol) in dimethylformamide (25 mL) was stirred at room temperature for 20 minutes. A solution of 2,2-dimethylpropylamine (0.96 g, 11.0 mmol) and N,N-diisopropylethylamine (1.42 g, 11.0 mmol) in a small amount of dimethylformamide was added. Stirring was continued for 0.5 hour at room temperature. Ethyl acetate was added and the reaction mixture was extracted twice with water. The solvent was evaporated in vacuo yielding the title compound, which was used without further purification.

Aufarbeitung

  1. extractionthe reaction mixture was extracted twice with water
  2. customThe solvent was evaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-4d7fde8ce9b046089671aff8df6d3027
Quelldatensatz
uspto-grants-2007_10
Patentnummer
US07279470B2

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