Water → Pyridine, 2-[(6-methoxy-3-pyridinyl)oxy]-5-(trifluoromethyl)-

HRID 1179695

Reaktionsgleichung

Reaktionsgleichung von HRID 1179695
[OH:1][C:2]1[CH:3]=[CH:4][C:5]([O:8][CH3:9])=[N:6][CH:7]=1.Cl[C:11]1[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][N:12]=1.[OH-].[K+].O>CS(C)=O>[CH3:9][O:8][C:5]1[CH:4]=[CH:3][C:2]([O:1][C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][N:12]=2)=[CH:7][N:6]=1

Komponenten

6

Edukt 4

HCID 962WaterHCID 14797Potassium HydroxideHCID 923422-Chloro-5-(trifluoromethyl)pyridineHCID 116223355-Hydroxy-2-methoxypyridine

Produkt 1

HCID 22047745Pyridine, 2-[(6-methoxy-3-pyridinyl)oxy]-5-(trifluoromethyl)-Ausbeute 95 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 679Dimethyl SulfoxideLösungsmittel

Versuchsvorschrift

A solution of 5-hydroxy-2-methoxypyridine (1.25 g, 10.0 mmol), 2-chloro-5-trifluoromethylpyridine (1.82 g, 10.0 mmol) and potassium hydroxide (85% pure, 1.08 g, 10.0 mmol) in dimethyl sulfoxide (25 mL) was heated at 90° C. for 2.5 hours. The solution was cooled to room temperature and poured slowly into water (200 mL). After cooling with an external ice-bath, the precipitate was collected by suction, washed thoroughly with water and dried in a vacuum oven at 45° C., yielding the title compound (2.56 g, 95% yield).

Aufarbeitung

  1. temperatureAfter cooling with an external ice-bath
  2. customthe precipitate was collected by suction
  3. washwashed thoroughly with water
  4. customdried in a vacuum oven at 45° C.

Quellen und Nachweise

ORD-Eintrag
ord-09886bbf47804553bf7495b4399e2b6a
Quelldatensatz
uspto-grants-2007_10
Patentnummer
US07279470B2

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