Trifluoroacetic acid → Trifluoroacetic acid

HRID 1179951

Reaktionsgleichung

Reaktionsgleichung von HRID 1179951
C(OC(=O)[NH:7][CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([O:16][C:17](=[O:26])[N:18]([CH3:25])[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[CH:12][CH:11]=1)(C)(C)C.[C:28]([OH:34])([C:30]([F:33])([F:32])[F:31])=[O:29]>C(Cl)Cl>[NH2:7][CH2:8][CH2:9][C:10]1[CH:11]=[CH:12][C:13]([O:16][C:17](=[O:26])[N:18]([CH3:25])[C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)=[CH:14][CH:15]=1.[C:28]([OH:34])([C:30]([F:33])([F:32])[F:31])=[O:29]

Komponenten

5

Edukt 2

HCID 6422Trifluoroacetic acidHCID 69518850{2-[4-(Methyl-phenyl-carbamoyloxy)-phenyl]-ethyl}-carbamic acid tertbutyl ester

Produkt 2

HCID 6422Trifluoroacetic acidHCID 69520583Methyl-phenyl-carbamic acid 4-(2-amino-ethyl)phenyl Ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

{2-[4-(Methyl-phenyl-carbamoyloxy)-phenyl]-ethyl}-carbamic acid tertbutyl ester(3.7 g; 10 mmol) from above was dissolved in CH2Cl2 (90 mL). Addition of TFA (6 mL) and stirring for 4 h. The reaction mixture was evaporated to dryness and dried in vacuo at 50° C. overnight producing the title compound as a TFA salt in quantitative yield as yellow hygroscopic crystals.

Aufarbeitung

  1. customThe reaction mixture was evaporated to dryness
  2. customdried in vacuo at 50° C. overnight

Quellen und Nachweise

ORD-Eintrag
ord-72fdee7c52474c0a818034ace34960c5
Quelldatensatz
uspto-grants-2007_10
Patentnummer
US07279470B2

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