HCID 10104631, Verbindung → Ammonia
Reaktionsgleichung
Cl[C:2]1[N:3]=[N:4][C:5]([N:8]2[CH2:14][CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[CH:6][CH:7]=1>[Pd].C(O)C>[NH3:3].[N:3]1[CH:2]=[CH:7][CH:6]=[C:5]([N:8]2[CH2:14][CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[N:4]=1Komponenten
5
Edukt 1
Produkt 2
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
A mixture of 1-(3-chloro-6-pyridazinyl)-homopiperazine (5.56 g, 26.1 mmol), palladium on carbon (2.1 g, 10%) and ethanol (150 ml) was stirred under hydrogen overnight. The crude product was filtered through celite and evaporated. Chromatography on silica gel with dichloromethane, methanol and conc. ammonia (89:10:1) gave the title compound as free base. Yield 2.78 g, 60%, 185.0-186.9° C.
Aufarbeitung
- filtrationThe crude product was filtered through celite
- customevaporated
Quellen und Nachweise
- ORD-Eintrag
- ord-23663dc88f1845229b05d372bb5f7587
- Quelldatensatz
- uspto-grants-2007_10
- Patentnummer
- US07282494B2
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