Hydrazine hydrate (1:1) → HCID 21960236, Verbindung

HRID 1181264

Reaktionsgleichung

Reaktionsgleichung von HRID 1181264
[Cl:1][C:2]1[C:3]2[S:10][CH:9]=[C:8]([CH3:11])[C:4]=2[N:5]=[CH:6][N:7]=1.O.[NH2:13][NH2:14]>C(O)C>[ClH:1].[CH3:11][C:8]1[C:4]2[N:5]=[CH:6][N:7]=[C:2]([NH:13][NH2:14])[C:3]=2[S:10][CH:9]=1

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 27775864-Chloro-7-methylthieno(3,2-d)pyrimidine

Produkt 1

HCID 21960236HCID 21960236, VerbindungAusbeute 88 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A suspension of 4-chloro-7-methylthieno[3,2-d]pyrimidine (4, 3.1 g, 17 mmol) and hydrazine monohydrate (3.5 mL, 72 mmol) in ethanol (34 mL) was heated at reflux for 1 hour. After cooling to room temperature, the solid product was collected by vacuum filtration to give (7-methylthieno[3,2-d]pyrimidin-4-yl)hydrazine hydrochloride (3.2 g, 88% yield) as a white solid.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureat reflux for 1 hour
  3. filtrationthe solid product was collected by vacuum filtration

Quellen und Nachweise

ORD-Eintrag
ord-39a22508340f48f6a4f3eb4aa3f801b3
Quelldatensatz
uspto-grants-2007_10
Patentnummer
US07285556B2

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