2,5-Diaminoanisole → 3-(4-Amino-3-methoxyphenyl)-6-(4-chlorophenyl)thieno[3,2-d]pyrimidin-4(3H)-one

HRID 1181368

Reaktionsgleichung

Reaktionsgleichung von HRID 1181368
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:16][C:15]3[C:14](=[O:17])[N:13]([C:18]4[CH:23]=[CH:22][C:21](O)=[C:20]([O:25][CH3:26])[CH:19]=4)[CH:12]=[N:11][C:10]=3[CH:9]=2)=[CH:4][CH:3]=1.COC1C=C([NH2:35])C=CC=1N>>[NH2:35][C:21]1[CH:22]=[CH:23][C:18]([N:13]2[C:14](=[O:17])[C:15]3[S:16][C:8]([C:5]4[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=4)=[CH:9][C:10]=3[N:11]=[CH:12]2)=[CH:19][C:20]=1[O:25][CH3:26]

Komponenten

3

Edukt 2

HCID 213792,5-DiaminoanisoleHCID 589808956-(4-chlorophenyl)-3-(4-hydroxy-3-methoxyphenyl)thieno[3,2-d]pyrimidin-4(3H)-one

Produkt 1

HCID 589808433-(4-Amino-3-methoxyphenyl)-6-(4-chlorophenyl)thieno[3,2-d]pyrimidin-4(3H)-oneAusbeute 50 %

Versuchsvorschrift

The product was prepared according to the manner of 6-(4-chlorophenyl)-3-(4-hydroxy-3-methoxyphenyl)thieno[3,2-d]pyrimidin4(3H)-one (the preparation of which may be found in Example K1), using 2-methoxybenzene-1,4-diamine to give the product as a yellow powder (0.19 g, 50%). LCMS m/z 384 (MH+). 1H NMR (300 MHz, DMSO-d6) δ 8.40 (s, 1H), 8.00 (s, 1H), 7.95 (d, 2H), 7.60 (d, 2H), 7.00 (s, 1H), 6.80 (d, 1H), 6.75 (d, 1H), 5.05 (s, 2H), 3.80 (s, 3H), ppm.

Aufarbeitung

  1. customThe product was prepared
  2. customthe preparation of which

Quellen und Nachweise

ORD-Eintrag
ord-fffb4a7bb29d48ffa001832353e96b33
Quelldatensatz
uspto-grants-2007_10
Patentnummer
US07285557B2

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