8-fluoro-5-nitroisoquinoline → 8-Fluoroisoquinolin-5-amine

HRID 1181403Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1181403
[F:1][C:2]1[CH:3]=[CH:4][C:5]([N+:12]([O-])=O)=[C:6]2[C:11]=1[CH:10]=[N:9][CH:8]=[CH:7]2.[H][H]>CO.[Pd]>[F:1][C:2]1[C:11]2[CH:10]=[N:9][CH:8]=[CH:7][C:6]=2[C:5]([NH2:12])=[CH:4][CH:3]=1

Komponenten

5

Edukt 2

HCID 670018188-fluoro-5-nitroisoquinolineHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 450907648-Fluoroisoquinolin-5-amineAusbeute 40,2 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To a nitrogen flushed solution of 8-fluoro-5-nitroisoquinoline (Description 42; 1.33 g, 6.9 mmol) in methanol (100 ml) was added 10% palladium on carbon (500 mg) and the resulting mixture stirred under a balloon of hydrogen for 3.5 hours. The catalyst was removed by filtration and the filtrate evaporated to dryness. The residue was purifted by MPLC (Biotage Flash™ 40) eluting with 2% MeOH in dichloromethane to give the title compound (450 mg, 40%) as a yellow solid.

Aufarbeitung

  1. customThe catalyst was removed by filtration
  2. customthe filtrate evaporated to dryness
  3. washeluting with 2% MeOH in dichloromethane

Quellen und Nachweise

ORD-Eintrag
ord-8da809e3d33542c9a8a9991cf753f64a
Quelldatensatz
uspto-grants-2007_10
Patentnummer
US07285563B2

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