Hydrazine hydrate (1:1) → 6-hydrazino-1-isobutylpyrimidine-2,4(1H,3H)-dione
Reaktionsgleichung
O.[NH2:2][NH2:3].Cl[C:5]1[N:10]([CH2:11][CH:12]([CH3:14])[CH3:13])[C:9](=[O:15])[NH:8][C:7](=[O:16])[CH:6]=1>C(O)C>[NH:2]([C:5]1[N:10]([CH2:11][CH:12]([CH3:14])[CH3:13])[C:9](=[O:15])[NH:8][C:7](=[O:16])[CH:6]=1)[NH2:3]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
Hydrazine hydrate (5.9 ml) was added to a solution of 6-chloro-1-isobutylpyrimidine-2,4(1H,3H)-dione synthesized according to procedure described in Heterocycles, 1990, 31(9), 1641-1646, (5.9 g) in ethanol (100 ml). The mixture was heated at reflux for 16 hours, cooled to room temperature and then evaporated under reduced pressure. The residue was crystallized from ethanol to give the subtitle compound (5.8 g).