Pyridine → HCID 69359775, Verbindung

HRID 1182117Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1182117
[CH2:1]([N:3]1[N:7]=[N:6][C:5]([NH2:8])=[N:4]1)[CH3:2].N1C=CC=CC=1.[C:15]1([O:21][C:22](Cl)=[O:23])[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>C1COCC1>[C:15]1([O:21][C:22](=[O:23])[NH:8][C:5]2[N:6]=[N:7][N:3]([CH2:1][CH3:2])[N:4]=2)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Komponenten

5

Edukt 3

HCID 1049PyridineHCID 15891Phenyl chloroformateHCID 42745882-ethyl-2H-tetrazol-5-amine

Produkt 1

HCID 69359775HCID 69359775, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Versuchsvorschrift

A solution of 2-ethyl-2H-tetrazol-5-ylamine (0.1 g, 0.88 mmol) in dry THF (2 ml) is treated with pyridine (0.09 ml, 1.10 mmol) followed by a solution of phenylchloroformate (0.11 ml, 0.911 mmol) in THF (1 ml). The reaction mixture is stirred at ambient temperature for 1.5 hours, then partitioned between ethylacetate and water. The ethylacetate phase is dried over magnesium sulphate and evaporated to afford (2-Ethyl-2H-tetrazol-5-yl)-carbamic acid phenyl ester as a white solid. 1H NMR (CDCl3, 400 MHz) δ, 7.90 (1H, brs), 7.30 (2H, m), 7.15, (3H, m), 4.60 (2H, q) 1.60 (3H, t).

Aufarbeitung

  1. custompartitioned between ethylacetate and water
  2. dry with materialThe ethylacetate phase is dried over magnesium sulphate
  3. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-472be5302cae42c9a20a401a9028f0c1
Quelldatensatz
uspto-grants-2007_10
Patentnummer
US07288537B2

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