4-Methylmorpholine → HCID 86762290, Verbindung

To a solution of 3,5-diamino-6-chloro-pyrazine-2-carboxylic acid (161 mg, 0.86 mmol) and HATU (325 mg, 0.86 mmol) in DMF (10 mL) is added N-methylmorpholine (0.38 mL, 3.42 mmol) followed by N*2*-(2,4-dimethoxy-benzyl)-5-[4-((R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-phenyl]-pentane-1,2-diamine (391 mg, 0.86 mmol) and the mixture is stirred at RT overnight. The solvent is removed in vacuo. To the crude residue is added water (10 mL), which is then decanted off to leave an orange solid that is washed with diethyl ether (10 mL) and dried in vacuo at 50° C. to afford the title compound. [M+H]+ 629.

1. customThe solvent is removed in vacuo
2. additionTo the crude residue is added water (10 mL), which
3. customis then decanted off
4. customto leave an orange solid
5. washthat is washed with diethyl ether (10 mL)
6. customdried in vacuo at 50° C.

ORD-Eintrag

ord-f39531e710904348a24f868962145c96

Quelldatensatz

uspto-grants-2014_03

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08664228B2