Hydrazine hydrate (1:1) → ((S)-1-Aminomethyl-butyl)-carbamic acid tert-butyl ester

HRID 1183020Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1183020
[C:1]([O:5][C:6](=[O:24])[NH:7][C@H:8]([CH2:12][N:13]1C(=O)C2C(=CC=CC=2)C1=O)[CH2:9][CH2:10][CH3:11])([CH3:4])([CH3:3])[CH3:2].O.NN>CCO.C(Cl)Cl>[C:1]([O:5][C:6](=[O:24])[NH:7][C@H:8]([CH2:12][NH2:13])[CH2:9][CH2:10][CH3:11])([CH3:2])([CH3:3])[CH3:4]

Komponenten

5

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 66917015[(S)-1-(1,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-butyl]-carbamic acid tert-butyl ester

Produkt 1

HCID 86651886((S)-1-Aminomethyl-butyl)-carbamic acid tert-butyl ester

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A mixture of [(S)-1-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-butyl]-carbamic acid tert-butyl ester (2.80 g, 8.42 mmol) and hydrazine monohydrate (3.0 mL, 60.0 mmol) in EtOH (50 mL) and DCM (75 mL) is stirred at RT for 48 h. The precipitated solid is collected by filtration and washed with DCM to afford the crude product as a white solid that is used without further purification.

Aufarbeitung

  1. filtrationThe precipitated solid is collected by filtration
  2. washwashed with DCM

Quellen und Nachweise

ORD-Eintrag
ord-fe409e3bf567465a909fe71aac508a74
Quelldatensatz
uspto-grants-2014_03
Patentnummer
US08664228B2

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