Potassium Carbonate → HCID 67401954, Verbindung

HRID 1186371

Reaktionsgleichung

Reaktionsgleichung von HRID 1186371
[Cl:1][C:2]1[S:3][C:4]([CH:7]=[O:8])=[CH:5][N:6]=1.C(=O)([O-])[O-].[K+].[K+].[F:15][C:16]([Si](C)(C)C)([F:18])[F:17]>CN(C)C=O>[Cl:1][C:2]1[S:3][C:4]([CH:7]([OH:8])[C:16]([F:18])([F:17])[F:15])=[CH:5][N:6]=1

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 552549(Trifluoromethyl)trimethylsilaneHCID 14797652-Chloro-1,3-thiazole-5-carbaldehyde

Produkt 1

HCID 67401954HCID 67401954, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

According to Reference Example 8-2, by use of 2-chlorothiazole-5-carbaldehyde (300 mg, 2.03 mmol) dissolved in N,N-dimethylformamide (4 mL), potassium carbonate (56 mg, 0.41 mmol) and (trifluoromethyl)trimethylsilane (0.360 mL, 2.44 mmol), the mixture was stirred and reacted at room temperature for 1.3 hours. Then, purification by preparative thin-layer chromatography (chloroform/methanol=15/1) was performed to give

Aufarbeitung

  1. customreacted at room temperature for 1.3 hours
  2. customThen, purification by preparative thin-layer chromatography (chloroform/methanol=15/1)
  3. customto give

Quellen und Nachweise

ORD-Eintrag
ord-9fb403dcf9c6448d8721f7ff0532fff1
Quelldatensatz
uspto-grants-2014_03
Patentnummer
US08673908B2

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