Potassium Carbonate → 2,2,2-Trifluoro-1-(2-morpholinothiazol-5-yl)ethanol

HRID 1186376

Reaktionsgleichung

Reaktionsgleichung von HRID 1186376
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[S:8][C:9]([CH:12]=[O:13])=[CH:10][N:11]=2)[CH2:3][CH2:2]1.C(=O)([O-])[O-].[K+].[K+].[F:20][C:21]([Si](C)(C)C)([F:23])[F:22]>CN(C)C=O>[F:20][C:21]([F:23])([F:22])[CH:12]([C:9]1[S:8][C:7]([N:4]2[CH2:5][CH2:6][O:1][CH2:2][CH2:3]2)=[N:11][CH:10]=1)[OH:13]

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 552549(Trifluoromethyl)trimethylsilaneHCID 14797702-(Morpholin-4-yl)-1,3-thiazole-5-carbaldehyde

Produkt 1

HCID 674017402,2,2-Trifluoro-1-(2-morpholinothiazol-5-yl)ethanolAusbeute 65,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

According to Reference Example 8-2, by use of 2-morpholinothiazole-5-carbaldehyde (177 mg, 0.893 mmol) dissolved in N,N-dimethylformamide (5.3 mL), potassium carbonate (25 mg, 0.18 mmol) and (trifluoromethyl)trimethylsilane (0.198 mL, 1.34 mmol), the mixture was stirred and reacted at room temperature for 2.3 hours. Then, purification by preparative thin-layer chromatography (chloroform/methanol=15/1) was performed to give 2,2,2-trifluoro-1-(2-morpholinothiazol-5-yl)ethanol (Compound DY) (156 mg, yield: 65%).

Aufarbeitung

  1. customreacted at room temperature for 2.3 hours
  2. customThen, purification by preparative thin-layer chromatography (chloroform/methanol=15/1)

Quellen und Nachweise

ORD-Eintrag
ord-c2161b8b710a4619b109609db1ebd983
Quelldatensatz
uspto-grants-2014_03
Patentnummer
US08673908B2

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