Reaktionsgleichung
Br[C:2]1[N:6]2[CH:7]=[CH:8][N:9]=[C:10]([NH:11][CH2:12][CH2:13][OH:14])[C:5]2=[N:4][CH:3]=1.CS[C:17]1[N:22]=[C:21]([Sn](CCCC)(CCCC)CCCC)[CH:20]=[CH:19][N:18]=1.[CH:36]([NH2:39])([CH3:38])[CH3:37]>>[CH:36]([NH:39][C:17]1[N:18]=[C:19]([C:2]2[N:6]3[CH:7]=[CH:8][N:9]=[C:10]([NH:11][CH2:12][CH2:13][OH:14])[C:5]3=[N:4][CH:3]=2)[CH:20]=[CH:21][N:22]=1)([CH3:38])[CH3:37]Komponenten
4
Versuchsvorschrift
2-[3-(2-Isopropylamino-pyrimidin-4-yl)-imidazo[1,2-a]pyrazin-8-ylamino]-ethanol was prepared by a process analogous to that described in Example 12 starting from 2-(3-bromo-imidazo[1,2-a]pyrazin-8-ylamino)-ethanol (from Example 2 supra), 2-methylsulfanyl-4-tributylstannanyl-pyrimidine, and isopropylamine. LC-MS: [M+H]+ 314.3.
Quellen und Nachweise
- ORD-Eintrag
- ord-2132ea03211a4527b09f1734c294e713
- Quelldatensatz
- uspto-grants-2014_03
- Patentnummer
- US08673905B2
Verknüpfte Notizen
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