Hydrochloric Acid → 2,6-Difluoro-3-nitrobenzoic acid

HRID 1187294

Reaktionsgleichung

Reaktionsgleichung von HRID 1187294
C([O:8][C:9](=[O:21])[C:10]1[C:15]([F:16])=[CH:14][CH:13]=[C:12]([N+:17]([O-:19])=[O:18])[C:11]=1[F:20])C1C=CC=CC=1.[OH-].[Na+].Cl>O1CCCC1.O>[F:20][C:11]1[C:12]([N+:17]([O-:19])=[O:18])=[CH:13][CH:14]=[C:15]([F:16])[C:10]=1[C:9]([OH:21])=[O:8]

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 583170052,6-Difluoro-3-nitro-benzoic acid benzyl ester

Produkt 1

HCID 3026292,6-Difluoro-3-nitrobenzoic acidAusbeute 56,8 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To 2,6-difluoro-3-nitro-benzoic acid benzyl ester (47, 750 mg, 2.6 mmol) in 4 mL of tetrahydrofuran and 2 mL of water, sodium hydroxide (0.2 g, 5.0 mmol) is added and the reaction is stirred for 2 hours. The reaction is acidified with dilute hydrochloric acid and extracted with ethyl acetate. The organic layer is concentrated under vacuum to provide the desired compound (48, 300 mg).

Aufarbeitung

  1. extractionextracted with ethyl acetate
  2. concentrationThe organic layer is concentrated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-c579b3f9030948b38928ca0b846d3113
Quelldatensatz
uspto-grants-2014_03
Patentnummer
US08673928B2

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