Nitrogen → HCID 86664910, Verbindung

HRID 1189383Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1189383
N#N.[CH2:3]([C:5]1[O:6][C:7]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[C:8]([C:10](O)=[O:11])[N:9]=1)[CH3:4].CN(C=O)C.C(Cl)(=O)C([Cl:27])=O>C1(C)C=CC=CC=1>[CH2:3]([C:5]1[O:6][C:7]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[C:8]([C:10]([Cl:27])=[O:11])[N:9]=1)[CH3:4]

Komponenten

6

Edukt 4

HCID 947NitrogenHCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 669290412-Ethyl-5-phenyl-oxazole-4-carboxylic acid

Produkt 1

HCID 86664910HCID 86664910, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), a suspension of 2-ethyl-5-phenyl-oxazole-4-carboxylic acid (54 mg, 0.25 mmol) in toluene (1.0 mL) was treated with a drop of DMF followed by oxalyl chloride (0.08 mL, 0.86 mmol) and the resulting yellow solution was stirred at rt for 30 min. The solvent was then removed under reduced pressure (coevaporation with toluene) to give 2-ethyl-5-phenyl-oxazole-4-carbonyl chloride.

Aufarbeitung

  1. customThe solvent was then removed under reduced pressure (coevaporation with toluene)

Quellen und Nachweise

ORD-Eintrag
ord-05b66699d4c54163a17d1a96e04fa562
Quelldatensatz
uspto-grants-2014_03
Patentnummer
US08674111B2

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