Tert-Butylamine → HCID 67134197, Verbindung

HRID 1189455Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1189455
F[C:2]1[C:11]([N+:12]([O-:14])=[O:13])=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([CH2:15][O:16][CH3:17])[CH:3]=1.[C:18]([NH2:22])([CH3:21])([CH3:20])[CH3:19]>N1C=CC=CC=1>[C:18]([NH:22][C:2]1[C:11]([N+:12]([O-:14])=[O:13])=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([CH2:15][O:16][CH3:17])[CH:3]=1)([CH3:21])([CH3:20])[CH3:19]

Komponenten

4

Edukt 2

HCID 6385Tert-ButylamineHCID 58575197HCID 58575197, Verbindung

Produkt 1

HCID 67134197HCID 67134197, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

To a mixed liquid of 5.50 g of methyl 4-fluoro-2-(methoxymethyl)-5-nitrobenzoate and 55.0 mL of pyridine was added 7.20 mL of tert-butylamine, followed by stirring at room temperature overnight. The solvent was evaporated under reduced pressure, and to the residue was added water. Then, 1 M hydrochloric acid was added thereto to adjust the pH to about 4, and the precipitated solid was collected by filtration and dried under reduced pressure to obtain 6.82 g of methyl 4-(tert-butylamino)-2-(methoxymethyl)-5-nitrobenzoate as a yellow solid.

Aufarbeitung

  1. customThe solvent was evaporated under reduced pressure
  2. additionto the residue was added water
  3. additionThen, 1 M hydrochloric acid was added
  4. filtrationthe precipitated solid was collected by filtration
  5. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-cc460e5a5ce349f8a9f5f0907e3d0bf7
Quelldatensatz
uspto-grants-2014_03
Patentnummer
US08674096B2

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