Acetic Acid → 3-Amino-2,4-dichlorobenzoic acid

HRID 1189606Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1189606
C([NH:4][C:5]1[C:6]([Cl:15])=[C:7]([CH:11]=[CH:12][C:13]=1[Cl:14])[C:8]([OH:10])=[O:9])(=O)C.C(O)(=O)C>Cl>[NH2:4][C:5]1[C:6]([Cl:15])=[C:7]([CH:11]=[CH:12][C:13]=1[Cl:14])[C:8]([OH:10])=[O:9]

Komponenten

4

Edukt 2

HCID 176Acetic AcidHCID 198331103-Acetamido-2,4-dichlorobenzoic acid

Produkt 1

HCID 152782343-Amino-2,4-dichlorobenzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Versuchsvorschrift

3-Acetylamino-2,4-dichloro-benzoic acid (21.0 g, 84.6 mmol) is stirred in 6 M aq HCl-solution (120 mL) and acetic acid (250 mL) at reflux for 24 h. The reaction mixture is cooled, concentrated, diluted with water and concentrated again. The residue is diluted with water, stirred under cooling and filtered. The filtercake is washed and dried to give the sub-title compound.

Aufarbeitung

  1. temperatureThe reaction mixture is cooled
  2. concentrationconcentrated
  3. additiondiluted with water
  4. concentrationconcentrated again
  5. additionThe residue is diluted with water
  6. temperatureunder cooling
  7. filtrationfiltered
  8. washThe filtercake is washed
  9. customdried

Quellen und Nachweise

ORD-Eintrag
ord-0fb18df8ad46480fb98862853207123a
Quelldatensatz
uspto-grants-2014_03
Patentnummer
US08674113B2

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