1,1'-Thiocarbonyldi-2(1H)-pyridone → N-(2,4-Dichloro-3-isothiocyanato-benzyl)-2-methyl-2-fluoro-propionamide

HRID 1189626Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1189626
[C:1](N1C=CC=CC1=O)(N1C=CC=CC1=O)=[S:2].[NH2:17][C:18]1[C:19]([Cl:33])=[C:20]([CH:29]=[CH:30][C:31]=1[Cl:32])[CH2:21][NH:22][C:23](=[O:28])[C:24]([CH3:27])([F:26])[CH3:25]>O.O1CCOCC1>[Cl:33][C:19]1[C:18]([N:17]=[C:1]=[S:2])=[C:31]([Cl:32])[CH:30]=[CH:29][C:20]=1[CH2:21][NH:22][C:23](=[O:28])[C:24]([CH3:25])([F:26])[CH3:27]

Komponenten

5

Edukt 2

HCID 8531621,1'-Thiocarbonyldi-2(1H)-pyridoneHCID 67957110N-(3-Amino-2,4-dichloro-benzyl)-2-methyl-2-fluoro-propionamide

Produkt 1

HCID 86666461N-(2,4-Dichloro-3-isothiocyanato-benzyl)-2-methyl-2-fluoro-propionamide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 312751,4-DioxaneLösungsmittel2×

Versuchsvorschrift

1,1′-Thiocarbonyldi-2-pyridone (1.21 g, 5.2 mmol) is added to a mixture of N-(3-amino-2,4-dichloro-benzyl)-2-methyl-2-fluoro-propionamide (1.32 g, 4.7 mmol) and dioxane (25 mL) and it is stirred at reflux for 2 d. The mixture is diluted with water, most of the dioxane is removed under reduced pressure and the resulting precipitate is collected by filtration, washed with water and dried.

Aufarbeitung

  1. temperatureat reflux for 2 d
  2. customis removed under reduced pressure
  3. filtrationthe resulting precipitate is collected by filtration
  4. washwashed with water
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-201a2d394466413fafc6c04f8b76c7db
Quelldatensatz
uspto-grants-2014_03
Patentnummer
US08674113B2

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