Hydrochloric Acid → 2-Chloro-4-(methylamino)-5-nitrobenzoic acid

HRID 1189642Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1189642
[CH3:1][NH2:2].[Cl:3][C:4]1[CH:12]=[C:11](F)[C:10]([N+:14]([O-:16])=[O:15])=[CH:9][C:5]=1[C:6]([OH:8])=[O:7].Cl>O>[Cl:3][C:4]1[CH:12]=[C:11]([NH:2][CH3:1])[C:10]([N+:14]([O-:16])=[O:15])=[CH:9][C:5]=1[C:6]([OH:8])=[O:7]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 6329Methylamine2×HCID 72108282-Chloro-4-fluoro-5-nitrobenzoic Acid

Produkt 1

HCID 679575072-Chloro-4-(methylamino)-5-nitrobenzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Versuchsvorschrift

Methylamine (40% aq solution, 8.25 mL) is added to an ice-cooled mixture of 2-chloro-4-fluoro-5-nitro-benzoic acid (7.00 g, 31 mmol) and 70 mL water. After 2 h additional 0.5 mL methylamine solution is added and it is stirred for additional 3 h. Then 200 mL of water and 47 mL 1N aq HCl are added and the resulting precipitate is filtered off, washed with water and dried.

Aufarbeitung

  1. temperaturecooled
  2. filtrationthe resulting precipitate is filtered off
  3. washwashed with water
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-8d60785c8f6441819d6d5a234b3e4897
Quelldatensatz
uspto-grants-2014_03
Patentnummer
US08674113B2

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