Urea → 4-(3-Cyanophenyl)-1H-benzo[h]quinazolin-2-one
Reaktionsgleichung
[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[C:12]([C:14]1[CH:15]=[C:16]([CH:19]=[CH:20][CH:21]=1)[C:17]#[N:18])=O.[NH2:22][C:23](N)=[O:24]>C(O)(=O)C>[C:17]([C:16]1[CH:15]=[C:14]([C:12]2[C:3]3[C:2](=[C:11]4[CH:10]=[CH:9][CH:8]=[CH:7][C:6]4=[CH:5][CH:4]=3)[NH:1][C:23](=[O:24])[N:22]=2)[CH:21]=[CH:20][CH:19]=1)#[N:18]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
To a solution of 3-(1-amino-2-naphthoyl)benzonitrile (200 mg, 0.734 mmol) in acetic acid (2 mL) was added urea (132 mg, 2.20 mmol). The mixture was heated under reflux for 18 hours. The reaction mixture was cooled to room temperature, and filtered. The obtained crystal was washed with ethyl acetate, and dried to give the titled compound as a yellow crystal (130 mg, yield 60%).