3-Hydroxyiminomethyl-4-(2,3-dichlorophenyl)pyrrole → Fenpiclonil

HRID 1194124Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1194124
O[N:2]=[CH:3][C:4]1[C:8]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([Cl:15])[C:10]=2[Cl:16])=[CH:7][NH:6][CH:5]=1.ON=CC1NC=C(C2C=CC=C(Cl)C=2Cl)C=1>C(OC(=O)C)(=O)C.C(OCC)(=O)C>[Cl:16][C:10]1[C:11]([Cl:15])=[CH:12][CH:13]=[CH:14][C:9]=1[C:8]1[C:4]([C:3]#[N:2])=[CH:5][NH:6][CH:7]=1

Komponenten

5

Edukt 2

HCID 1363937133-Hydroxyiminomethyl-4-(2,3-dichlorophenyl)pyrroleHCID 136393714Hydroxyiminomethyl-4-(2,3-dichlorophenyl)pyrrole

Produkt 1

HCID 91724Fenpiclonil

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 7918Acetic AnhydrideLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

3.2 g of the 3-hydroxyiminomethyl-4-(2,3-dichlorophenyl)pyrrole obtained in (b) are kept for 5 hours at c. 100° C. in 50 ml of acetic anhydride, then cooled to room temperature, poured into ice/NaOH, and the resultant mixture is stirred for 2 hours. The precipitate is dissolved in ethyl acetate, washed with water, and the ester phase is dried over magnesium sulfate. The residue is purifed by column chromatography (silica gel; elution with a 4:1 mixture of toluene/ethyl acetate). Melting point: 149°-151° C.

Aufarbeitung

  1. washwashed with water
  2. dry with materialthe ester phase is dried over magnesium sulfate
  3. washelution
  4. additionwith a 4:1 mixture of toluene/ethyl acetate)

Quellen und Nachweise

ORD-Eintrag
ord-e1c8184aac8748bcbeff2774099fc72f
Quelldatensatz
uspto-grants-1989_03
Patentnummer
US04812580

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