Hydrochloric Acid → HCID 18409104, Verbindung

HRID 1195163Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1195163
[CH3:1][NH:2][C:3]1([CH3:21])[CH2:12][CH2:11][CH2:10][C:9]2[N:8]=[C:7]([O:13]CC3C=CC=CC=3)[CH:6]=[CH:5][C:4]1=2.[ClH:22].[H][H]>C(O)C.CC(O)C.[Pd]>[ClH:22].[CH3:21][C:3]1([NH:2][CH3:1])[CH2:12][CH2:11][CH2:10][C:9]2[NH:8][C:7](=[O:13])[CH:6]=[CH:5][C:4]1=2

Komponenten

7

Edukt 3

HCID 313Hydrochloric AcidHCID 18409092HCID 18409092, VerbindungHCID 178418361HCID 178418361, Verbindung2×

Produkt 1

HCID 18409104HCID 18409104, VerbindungAusbeute 25 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittelHCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

5,6,7,8-Tetrahydro-N,5-dimethyl-2-(phenylmethoxy)-5-quinolinamine (6.3 g) in ethanol (500 ml) was acidified to ca pH2 with a solution of hydrochloric acid in 2-propanol. 10% Palladium-on-carbon (315 mg) was added and the mixture was shaken on Parr hydrogenation apparatus, starting at 55 psi of hydrogen, until hydrogen uptake ceased. The catalyst was collected and the filtrate was neutralized with 4-polyvinylpyridine. The solution was concentrated in vacuo to a volume of about 75 ml and diethyl ether was added. The precipitate was collected and recrystallized first from methanol and then from water/2-propanol to afford 1.3 g (25%) of product, mp 190°-195° C. (dec).

Aufarbeitung

  1. customThe catalyst was collected
  2. concentrationThe solution was concentrated in vacuo to a volume of about 75 ml and diethyl ether
  3. additionwas added
  4. customThe precipitate was collected
  5. customrecrystallized first from methanol

Quellen und Nachweise

ORD-Eintrag
ord-5ccc01776aa8412c8ea980b40c92ec73
Quelldatensatz
uspto-grants-1992_05
Patentnummer
US05110815

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