Dimethyl Sulfoxide → 3,3-Diethoxypropiononitrile
Reaktionsgleichung
[CH2:1]([O:3][CH:4]([O:7][CH2:8][CH3:9])[CH2:5]Br)[CH3:2].[C-:10]#[N:11].[Na+].CS(C)=O>O>[CH2:1]([O:3][CH:4]([O:7][CH2:8][CH3:9])[CH2:5][C:10]#[N:11])[CH3:2]Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A mixture of 8 g of bromo-acetaldehyde diethyl-acetal, 3 g of sodium-cyanide and 20 ml of dimethyl-sulfoxide is admixed at a temperature of 80° C. for 5 hours. The reaction mixture is poured on 80 ml of water, then twice extracted with 50 ml of chloroform. The chloroform extract is washed twice with 30 ml of water, dried on magnesium sulfate, then distilled in vacuo.
Aufarbeitung
- extractiontwice extracted with 50 ml of chloroform
- extractionThe chloroform extract
- washis washed twice with 30 ml of water
- customdried on magnesium sulfate
- distillationdistilled in vacuo
Quellen und Nachweise
- ORD-Eintrag
- ord-b84da5d5dbfa45d0a46ae7e2a8b4fbec
- Quelldatensatz
- uspto-grants-1992_05
- Patentnummer
- US05116402
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