Hydrochloric Acid → HCID 15024388, Verbindung

HRID 1196813

Reaktionsgleichung

Reaktionsgleichung von HRID 1196813
[NH:1]([C:15]([O:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:16])[C@H:2]([C:11]([O:13]C)=O)[CH2:3][C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1.[NH2:25][CH2:26][C:27]([NH:29][CH2:30][C:31]([OH:33])=[O:32])=[O:28].Cl>CS(C)=O>[NH:1]([C:15]([O:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:16])[C@H:2]([C:11]([NH:25][CH2:26][C:27]([NH:29][CH2:30][C:31]([OH:33])=[O:32])=[O:28])=[O:13])[CH2:3][C:4]1[CH:5]=[CH:6][C:7]([OH:10])=[CH:8][CH:9]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 11163GlycylglycineHCID 7010613N-[(Phenylmethoxy)carbonyl]-L-tyrosine methyl ester

Produkt 1

HCID 15024388HCID 15024388, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 679Dimethyl SulfoxideLösungsmittel

Versuchsvorschrift

330 mg (1 mmole) of Z-L-Tyr-OMe, 400 mg (2.2 mmole) of H-Gly-Gly-Ome, HCl were suspended in 5 mL DMSO and 5 mL 0.1 M tris-HCl, pH 8.9. 25 mg of α-chymotrypsin were added and the reaction stirred for 30 minutes. Five volumes of ice water were added, and the precipitate collected by filtration. Yield 312 mg (70%, based on acyl-donor). Amino acid analysis: tyr1.0,gly2.1.

Aufarbeitung

  1. addition25 mg of α-chymotrypsin were added
  2. filtrationthe precipitate collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-3045a12175474c26a96874021fff6f5d
Quelldatensatz
uspto-grants-1992_05
Patentnummer
US05116741

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