Hydrochloric Acid → 2-(2-Methyl-2-phenylpropan-1-yl)indene

HRID 11969

Reaktionsgleichung

Reaktionsgleichung von HRID 11969
Br[C:2]1[CH2:3][C:4]2[C:9]([CH:10]=1)=[CH:8][CH:7]=[CH:6][CH:5]=2.[CH3:11][C:12]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)([CH3:16])[CH2:13][Mg]Cl.Cl>CCOCC>[CH3:11][C:12]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)([CH3:16])[CH2:13][C:2]1[CH2:3][C:4]2[C:9]([CH:10]=1)=[CH:8][CH:7]=[CH:6][CH:5]=2

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 5755861H-Indene, 2-bromo-HCID 178418740HCID 178418740, Verbindung

Produkt 1

HCID 219769982-(2-Methyl-2-phenylpropan-1-yl)indene

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

A mixture of 2-bromoindene (2.0 g, 10.2 mmol) and 460 mg of Pd(AcO)2 in 60 mL of ether was treated with 21 mL of 2-methyl-2-phenyl-propanyl magnesium chloride (0.5 M in ether; 10.2 mmol). The mixture was refluxed for one hour, cooled to room temperature and treated with 30 mL of aqueous hydrochloric acid (5 percent). The reaction was worked-up and the product purified (hexanes/silica) as for 2-benzyl-indene. Yield: 1.6 g (63 percent).

Aufarbeitung

  1. temperatureThe mixture was refluxed for one hour
  2. customthe product purified (hexanes/silica) as for 2-benzyl-indene

Quellen und Nachweise

ORD-Eintrag
ord-4c2bcfdbb95d43638ee0afb3e5f26173
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07098356B2

Verknüpfte Notizen

Wird geladen…